The last decades, coronary microcirculation has become a very important territory because of its role in coronary circulation physiology and pathophysiology. Only its implication in coronary artery disease was known at the beginning, but subsequently its role in many others diseases was shown. The nontraditional pathophysiological construct sustains that myocardial microcirculatory dysfunction is the primary event, and the atherosclerotic plaque rupture or erosion is the secondary event. In some instances, the coronary microvascular dysfunction may be an epiphenomena, an important marker of risk or even a cause, thus becoming therapeutic target.
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Sleep Research & Treatment Center, Department of Psychiatry & Behavioral Health, Penn State University, College of Medicine, Hershey PA, USA.
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The Effect of Colchicine on Platelet Function Profiles in Patients with Stable Coronary Artery Disease: The ECLIPSE Pilot Study.
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January 2025
Adult Medicine, Department of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Introduction: This prospective, single-arm pharmacodynamic study assessed the effect of colchicine (COLC) [Strides Pharma UK Ltd, Watford, Hertfordshire, England] 0.5 mg administered orally once daily for 14 days on platelet reactivity with respect to aspirin reaction units (ARUs) and P2Y reaction units (PRUs).
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