A series of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles 6 were synthesized by the reaction of chalcone derivative of methylene-bis-thiazolidinone 5 with hydroxylamine hydrochloride. The chemical structures of newly synthesized compounds were elucidated by IR, 1H, 13C NMR, MS and elemental analyses. The compounds 6a-g were evaluated for their nematicidal activity against Ditylenchus myceliophagus and Caenorhabditis elegans, compound 6e and 6f showed appreciable nematicidal activity. Further the compounds 6a-g were screened for their antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185) and Trichophyton mentagrophytes (IFO 40996). The compounds 6b and 6f displayed notable antifungal activity against all the microorganisms employed. The activity of these two compounds is almost equal to the standard. It is also interesting to note that the compounds 6b, 6f and 6g showed activity towards C. albicans at the concentration of 3.75 microM, which is less than the concentration of the standard Amphotericin B.
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