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PKCα Activation via the Thyroid Hormone Membrane Receptor Is Key to Thyroid Cancer Growth.
Int J Mol Sci
November 2024
Instituto de Investigaciones Biomédicas (BIOMED), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina (UCA), Buenos Aires C1107AFB, Argentina.
Thyroid carcinoma (TC) is the most common endocrine neoplasia, with its incidence increasing in the last 40 years worldwide. The determination of genetic and/or protein markers for thyroid carcinoma could increase diagnostic precision. Accumulated evidence shows that Protein kinase C alpha (PKCα) contributes to tumorigenesis and therapy resistance in cancer.
View Article and Find Full Text PDFMediated Targeting // to Accelerate Thyroid Stimulating Hormone-Induced Hepatic Steatosis.
Hepat Med
November 2024
Department of Endocrinology, Shandong Provincial Hospital, Shandong University; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, 250021, People's Republic of China.
Purpose: Thyroid-stimulating hormone (TSH) has been identified as an independent risk factor for non-alcoholic fatty liver disease (NAFLD), TSH binds to the TSH receptor (TSHR) to exert its function. However, the underlying mechanisms by which TSHR influences NAFLD development remain unclear. This study investigates the role of in NAFLD progression.
View Article and Find Full Text PDFThyroid hormone remodels cortex to coordinate body-wide metabolism and exploration.
Cell
October 2024
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:
Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here, we find that thyroid hormone-a regulator of metabolism in many peripheral organs-directly activates cell-type-specific transcriptional programs in the frontal cortex of adult male mice.
View Article and Find Full Text PDFHormonal orchestra: mastering mitochondria's role in health and disease.
Endocrine
December 2024
Universite Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, Villeurbanne, France.
Article Synopsis
- Mitochondria play a crucial role in various cellular processes, influencing stress responses, immune functions, metabolism, and cell death through mechanisms like fission, fusion, and mitophagy.
- The interaction between hormones and mitochondria affects ATP production and impacts mitochondrial composition, which is vital in processes such as apoptosis and steroid hormone biosynthesis.
- Disruptions in mitochondrial function can lead to serious health issues, including neurodegenerative diseases and cancers, while hormones can enhance mitochondrial biogenesis and offer potential therapeutic applications.
The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper ().
Elife
August 2024
Marine Climate Change Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Japan.
Most teleost fishes exhibit a biphasic life history with a larval oceanic phase that is transformed into morphologically and physiologically different demersal, benthic, or pelagic juveniles. This process of transformation is characterized by a myriad of hormone-induced changes, during the often abrupt transition between larval and juvenile phases called metamorphosis. Thyroid hormones (TH) are known to be instrumental in triggering and coordinating this transformation but other hormonal systems such as corticoids, might be also involved as it is the case in amphibians.
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