AI Article Synopsis
- A comparative analysis of IL13 gene polymorphisms C(-1055)T and R130Q was conducted in Russian patients with atopic bronchial asthma (BA) and healthy donors, using 283 specimens from patients and 227 from donors.
- No significant association was found between these gene markers and the development of BA or total IgE concentration across the study samples.
- However, a notable link was identified between the C(-1055)T polymorphism and the severity of BA, with an odds ratio indicating that this polymorphism is associated with disease progression (OR = 2.39, p = 0.001).
Article Abstract
A comparative analysis of allele and genotype distribution of C(-1055)T and R130Q IL13 gene polymorphisms has been performed in Russian patients from the Moscow region. In the study, 283 DNA specimens of atopic bronchial asthma (BA) patients and 227 DNA specimens of healthy donors were used. No association of these markers with ABA development as well as with total IgE concentration has been found. Haplotype frequency analysis did not reveal significant difference between samples. However, significant association ofC(-1055)Tpolymorphism with the disease severity has been revealed (OR = 2.39, 95% confidence interval 1.44-3.98, p = 0.001). Therefore, C(-1055)T polymorphism was shown to be associated with atopic BA progression.
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