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Exploring memory-related network via dorsal hippocampus suppression.
Netw Neurosci
December 2024
Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Memory is a complex brain process that requires coordinated activities in a large-scale brain network. However, the relationship between coordinated brain network activities and memory-related behavior is not well understood. In this study, we investigated this issue by suppressing the activity in the dorsal hippocampus (dHP) using chemogenetics and measuring the corresponding changes in brain-wide resting-state functional connectivity (RSFC) and memory behavior in awake rats.
View Article and Find Full Text PDFClozapine rechallenge following myocarditis: a systematic review of rechallenge cases.
CNS Spectr
December 2024
Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Introduction And Objectives: Clozapine is the antipsychotic medication with the greatest efficacy in treatment-resistant schizophrenia (TRS). Unfortunately, clozapine is ceased in approximately 0.2% to 8.
View Article and Find Full Text PDFAn Investigation of the Sodium Nitroprusside Effects on Serum Lipids in an Animal Model of Schizophrenia by the Magnetic Resonance Study.
ACS Omega
December 2024
Laboratório de Química Biológica (LQB), Departamento de Química Orgânica, Instituto de Química, and INCT-Bio (CNPq), Universidade Estadual de Campinas (UNICAMP), Campinas, SP 13083-970, Brazil.
Schizophrenia (SCZ) is a multifactorial mental illness with limited knowledge concerning pathogenesis, contributing to the lack of effective therapies. More recently, the use of a nitric oxide donor named sodium nitroprusside (sNP) was suggested as a potential therapeutic drug for the treatment of SCZ. Despite the mixed results regarding the effectiveness of the sNP in reducing SCZ symptoms, successful trials on sNP in treatment-resistant SCZ were published.
View Article and Find Full Text PDFChronic activation of corticospinal tract neurons after pyramidotomy injury enhances neither behavioral recovery nor axonal sprouting.
bioRxiv
October 2024
Department of Biomedical Sciences, Marquette University, Milwaukee, WI, 53201.
Modulation of neural activity is a promising strategy to influence the growth of axons and improve behavioral recovery after damage to the central nervous system. The benefits of neuromodulation likely depend on optimization across multiple input parameters. Here we used a chemogenetic approach to achieve continuous, long-term elevation of neural activity in murine corticospinal tract (CST) neurons.
View Article and Find Full Text PDFSuccessful retreatment with clozapine combined with ursodeoxycholic acid after clozapine-induced hepatitis: A case report.
Asian J Psychiatr
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Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
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