Cutaneous adverse drug reactions are among the most common adverse drug reactions. Thise reactions to drugs can comprise a broad spectrum of clinical and histopathological features, with an important capacity to mimic numerous dermatological diseases, making the diagnose very difficult. We present the case of a patient, under immunomodulating treatment (TNFalpha antagonist and leflunomide), with a muco-cutaneous lichen planus-like eruption.
Download full-text PDF |
Source |
---|
Int J Dermatol
November 2024
Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Front Pharmacol
August 2024
Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet they can induce immune-related adverse events (irAEs), including cutaneous toxicities such as lichenoid eruptions. Pembrolizumab, a PD-1 inhibitor, is known for its association with lichen-planus-like reactions, while the side effect profile of combining immunotherapy with MK-4830, a novel fully human IgG4 monoclonal antibody that targets ILT-4, remains limited.
Case Report: We present a case of a 47-year-old female with metastatic breast cancer who developed a grade 2 Common Terminology Criteria for Adverse Events (CTCAE) lichenoid reaction after 9 months of MK-4830 and pembrolizumab use.
Indian J Dermatol
January 2023
Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China E-mail:
Front Immunol
March 2023
Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan.
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block key mediators of tumor-mediated immune evasion. The frequency of its use has increased rapidly and has extended to numerous cancers. ICIs target immune checkpoint molecules, such as programmed cell death protein 1 (PD-1), PD ligand 1 (PD-L1), and T cell activation, including cytotoxic T-lymphocyte-associated protein-4 (CTLA-4).
View Article and Find Full Text PDFJ Cutan Pathol
May 2023
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!