Unlabelled: Potential years of life lost (PYLL) represent an indicator of premature or untimely death and take into account the age at which deaths occur by giving greater weight to deaths at younger age and lower weight to death at older age.
Aim: This study represents a descriptive analysis of PYLL in district of Iaşi compared to country-wide level, during 2006 year.
Material And Method: Premature deaths have been assessed using following indicators: PYLL per 1000 population (male, female, total); male : female PYLL ratio; average PYLL per a premature death; average PYLL per death. Confidence interval CI95 has been used for an accurate comparison district of Iaşi - Romania.
Results: The recorded number of PYLL was 67.65 per 1000 population at national level and 54.02 per 1000 population in district of Iaşi (CI95 = 67.55-67.75). The average number of PYLL per a premature death was 18.21 in Iaşi compared to 20.71 for Romania (CI95 = 19.75-21.66), whereas the average number of PYLL per death was 5.6 for both levels. The values of PYLL by gender pointed out 74.59 per 1000 male population and 33.99 per 1000 female population in district of Iaşi.
Conclusion: The analysis of the premature deaths in Iasi revealed a lower loss of potential life years compared to values reported at national level. PYLL were twice more frequent among male than women. The favourable findings in Iaşi may be related to a decrease of infant mortality rate, with a significant contribution to PYLL values in this district.
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Heliyon
January 2025
Department of Public Health, Chung Shan Medical University, Taichung, 40201, Taiwan.
Objectives: This study used the Disability-Adjusted Life Years (DALYs) to quantify the long-term trends for four cancers (oral cancer, colorectal cancer, breast cancer, and cervical cancer) that have undergone cancer screening in Taiwan.
Methods: DALYs were calculated as the sum of Years of Life Lost (YLL) due to premature mortality and Years Lived with Disability (YLD). YLLs were determined using cancer-specific mortality data from the Health Promotion Administration (HPA), Ministry of Health and Welfare, based on age-specific life expectancy.
NPJ Aging
January 2025
Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Objective and subjective aging indicators reflect diverse biological and psychosocial processes, yet their combined association with premature mortality remains underexplored. This study aimed to investigate the association between a multidomain framework of aging indicators and premature mortality, addressing gaps in understanding cumulative effects. We included 369,741 UK Biobank participants initially free of cardiovascular disease (CVD) and cancer, followed until December 31, 2022.
View Article and Find Full Text PDFAntibiotics (Basel)
January 2025
Laboratory of Haematology and Blood Bank Unit, "Attikon" Hospital, National and Kapodistrian University of Athens Medical School, 12462 Athens, Greece.
: Neonatal sepsis is a serious condition with high mortality, especially in premature and low-birth-weight neonates. This study aims to examine whether the haemostatic profile of neonates with sepsis defers depending on the type of bacteria (Gram-positive or Gram-negative), by using the method of Rotational Thromboelastometry (ROTEM). : This single-centre prospective cohort study was conducted on 128 neonates with sepsis, including 95 cases caused by Gram-negative pathogens and 33 cases caused by Gram-positive bacteria.
View Article and Find Full Text PDFBiomedicines
January 2025
Department of Biochemistry and Molecular Biology, Faculty of Medicine, FSAEI HE N. I. Pirogov Russian National Research Medical University of MOH of Russia, 1 Ostrovitianov Str., 117997 Moscow, Russia.
Background: Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions.
Methods: In this study, the researchers conducted a broad parallel investigation of olivetol's effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia.
Biomedicines
December 2024
Department of Head and Skin, Faculty of Medicine, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
In the Sustainable Development Goals of the United Nations for 2030, mental health has been identified as a global priority, emphasizing the need to reduce the prevalence, morbidity, and premature mortality associated with mental disorders [...
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