Honokiol, a major phenolic constituent of Magnolia sp., has various pharmacological activities. To improve the solubility and antibacterial activity of honokiol against E. coli and P. aeruginosa, new honokiol-derivatives (honokiol-acetate, honokiol-succinic acid, honokiol-glycerol, honokiol-glycine, honokiol-glucose and honokiol-mannose) were synthesized and their solubility and antimicrobial activities were investigated. Among the tested compounds, honokiol-glycine showed improved water solubility and antibacterial activities against E. coli and P. aeruginosa when compared to honokiol.
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| http://dx.doi.org/10.1007/s12272-010-2225-7 | DOI Listing |
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