AI Article Synopsis
- Refractory status epilepticus poses challenges in treatment due to limited drug options and serious side effects, highlighting the need for alternative therapies.
- In a case study, a patient with nonlesional frontal lobe epilepsy experienced severe tonic seizures escalating to malignant status epilepticus.
- The use of verapamil, known for inhibiting multidrug transporters, led to a notable decrease in seizure frequency, prompting discussion on its potential role and associated risk factors in this context.
Article Abstract
In the scenario of refractory status epilepticus, the recommended approach of intensive care treatment is limited with respect to the available pharmacodynamic variability and its impeding, severe side effects. Alternative treatment options are therefore urgently needed. In the case described, a patient with nonlesional frontal lobe epilepsy had a high-frequency series of tonic seizures, which evolved into a malignant form of status epilepticus. Co-administration of verapamil, a potent multidrug transporter inhibitor, was followed by significant reduction in seizure frequency. We discuss the putative role of verapamil and the specific risk factors for this malignant treatment course.
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| http://dx.doi.org/10.1016/j.yebeh.2010.01.166 | DOI Listing |
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