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The Urgency Numeric Rating Scale: Psychometric Evaluation in Adults with Crohn's Disease.
Adv Ther
December 2024
Kennedy Institute, Translational Gastroenterology Unit and Biomedical Research Centre, University of Oxford, Oxford, UK.
Introduction: Bowel urgency has recently been recognized as a Crohn's disease (CD) symptom that substantially impacts patients' quality of life. The Urgency NRS is a single-item patient-reported outcome measure assessing bowel urgency severity in the past 24 h (0-10 scale). We aimed to evaluate the psychometric properties of the Urgency Numeric Rating Scale (NRS) in adults with moderately to severely active CD and to estimate thresholds for meaningful improvement and bowel urgency remission.
View Article and Find Full Text PDFDistinct trajectories of symptomatic response in ulcerative colitis during filgotinib therapy: A post hoc analysis from the SELECTION study.
United European Gastroenterol J
November 2024
Department of Gastroenterology, Nancy University Hospital, Nancy, France.
Article Synopsis
- Filgotinib, an oral medication for ulcerative colitis, has shown promising results in long-term treatment outcomes based on findings from the SELECTION trial.
- Researchers used group-based trajectory modeling to classify patients’ symptom responses over time, identifying five distinct patient groups based on their treatment responses.
- A majority of patients showed positive response trajectories, with factors such as recent diagnosis, usage of a higher filgotinib dose, and being biologic-naive linked to better outcomes and greater chances of achieving comprehensive disease control.
Adverse events after colonoscopy in a randomised colorectal cancer screening trial.
BMJ Open Gastroenterol
October 2024
Cancer Registry of Norway, Section for Colorectal Cancer Screening, Norwegian Institute of Public Health, Oslo, Norway
Article Synopsis
- A cross-sectional study in Norway examined adverse events related to colonoscopy in a randomized colorectal cancer screening trial, involving over 10,000 participants.
- Out of those, 2.4% experienced adverse events, ranging from mild to severe, with the most common issues being gastrointestinal bleeding and abdominal pain.
- Key risk factors for adverse events included older age, female sex, and specific medical treatments, highlighting the importance of awareness for endoscopists to reduce risks.
Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial.
Lancet Reg Health Eur
April 2024
Diabetes Research Centre, Leicester General Hospital, University of Leicester College of Life Sciences, Leicester, UK.
Background: An effective prescribing pathway for liraglutide 3 mg, an approved obesity pharmacotherapy, may improve treatment access. This trial compared a targeted prescribing pathway for liraglutide 3 mg with multiple stopping rules in specialist weight management services (SWMS) to standard SWMS care.
Methods: This phase four, two-year, multicentre, open-label, parallel-group, real-world randomized clinical trial (ClinicalTrials.
Ozanimod Differentially Impacts Circulating Lymphocyte Subsets in Patients with Moderately to Severely Active Crohn's Disease.
Dig Dis Sci
June 2024
Inflammatory Bowel Disease Center, Amsterdam University Medical Center, Amsterdam, Netherlands.
Background: Ozanimod showed efficacy and safety in the phase 2 STEPSTONE study conducted in patients with moderately to severely active Crohn's disease.
Aims: This analysis assessed the effects of ozanimod on circulating lymphocytes in Crohn's disease.
Methods: Patients received ozanimod 0.
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