AI Article Synopsis
- Testes from men with infertility issues like hypospermatogenesis and Sertoli cell-only syndrome show increased macrophages that produce interleukin-1β (IL-1β) and upregulated cyclooxygenase-2 (COX-2) in Leydig cells.
- The study found a positive relationship between IL-1β levels and COX-2 expression in the testes of infertile patients.
- It also demonstrated that IL-1β can induce COX-2 in both mouse Leydig cells and human macrophages, suggesting that IL-1β contributes to inflammation in the testes.
Article Abstract
As we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1β (IL-1β) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1β levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1β in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1β-dependent induction of testicular inflammatory states.
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| http://dx.doi.org/10.1016/j.fertnstert.2010.01.039 | DOI Listing |
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