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Article Abstract
Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115293 | PMC |
| http://dx.doi.org/10.1002/mds.22798 | DOI Listing |
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