AI Article Synopsis
- Calpinactam is a new anti-mycobacterial agent discovered from the fungal strain Mortierella alpina FKI-4905 through laboratory techniques like solvent extraction and chromatography.
- It specifically targets Mycobacteria, showing no activity against other microbes, including Gram-positive and Gram-negative bacteria, fungi, or yeasts.
- The compound effectively inhibited Mycobacterium smegmatis and Mycobacterium tuberculosis, with minimum inhibitory concentrations (MICs) of 0.78 and 12.5 microg/ml, respectively.
Article Abstract
Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 microg ml(-1), respectively.
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| http://dx.doi.org/10.1038/ja.2010.14 | DOI Listing |
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Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905.
J Antibiot (Tokyo)
April 2010
Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
Article Synopsis
- Calpinactam is a new anti-mycobacterial agent discovered from the fungal strain Mortierella alpina FKI-4905 through laboratory techniques like solvent extraction and chromatography.
- It specifically targets Mycobacteria, showing no activity against other microbes, including Gram-positive and Gram-negative bacteria, fungi, or yeasts.
- The compound effectively inhibited Mycobacterium smegmatis and Mycobacterium tuberculosis, with minimum inhibitory concentrations (MICs) of 0.78 and 12.5 microg/ml, respectively.
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