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| http://dx.doi.org/10.1016/j.jacc.2010.01.001 | DOI Listing |
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Chained occurrences of early afterdepolarizations may create a directional triggered activity to initiate reentrant ventricular tachyarrhythmias.
Comput Methods Programs Biomed
January 2025
Department of Physiology II, Kanazawa Medical University, Uchinada 920-0293, Japan. Electronic address:
Background And Objective: It has been believed that polymorphic ventricular tachycardia (VT) such as torsades de pointes (TdP) seen in patients with long QT syndromes is triggered by creating early afterdepolarization (EAD)-mediated triggered activity (TA). Although the mechanisms creating the TA have been studied intensively, characteristics of the arrhythmogenic (torsadogenic) substrates that link EAD developments to TA formation are still not well understood.
Methods: Computer simulations of excitation propagation in a homogenous two-dimensional ventricular tissue with an anisotropic conduction property were performed to characterize torsadogenic substrates that potentially form TA.
Management of patient with acute lymphocytic myocarditis and congenital long QT syndrome presenting with electrical storm and incessant Torsade de Pointes: a case report.
J Med Case Rep
December 2024
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia.
Background: This case highlights the management of concomitant acute myocarditis and congenital long QT syndrome with electrical storm and incessant Torsade de Pointes.
Case Presentation: An 18 years-old Southeast Asian para 1 abortus 0 (P1A0) postpartum patient with cesarean section owing to severe preeclampsia, acute lymphocytic myocarditis, and prolonged QT interval owing to long QT syndrome. She has incessant Torsade de Pointes treated with beta-blocker, lidocaine, overdrive pacing with a temporary transvenous pacemaker, left cardiac sympathetic denervation per video-assisted thoracoscopic surgery, and implantable cardioverter-defibrillator implantation.
Polygenic risk score for drug-induced long QT syndrome: independent validation in a real-world patient cohort.
Pharmacogenet Genomics
January 2025
Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan.
Article Synopsis
- Drug-induced long QT syndrome (diLQTS) is a serious side effect of over 150 medications that can lead to dangerous heart conditions; the study aimed to validate a genetic risk score for predicting this syndrome.
- Researchers analyzed data from a large cohort of patients taking high-risk QT-prolonging drugs and found that the risk score was significantly associated with diLQTS in White patients, indicating a higher likelihood of QT prolongation during treatment.
- Although the risk score showed promise in identifying high-risk individuals, the study was underpowered to confirm its effectiveness across African American and Asian populations, highlighting the need for larger sample sizes in diverse groups.
Association of anxiolytic drugs with Torsade de Pointes: a pharmacovigilance study of the Food and Drug Administration Adverse Event Reporting System.
J Pharm Policy Pract
September 2024
School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.
Article Synopsis
- This study investigated the link between anxiolytic drugs and the occurrence of Torsade de Pointes (TdP), a type of heart arrhythmia, using data from the FDA's Adverse Event Reporting System (FAERS) over a 30-year period.
- Researchers identified 260 cases of TdP linked to anxiolytics and employed various data-mining algorithms to analyze the risk associated with these drugs.
- The findings revealed six new signals of TdP risk linked to specific drugs, notably showing bromazepam and midazolam as the highest risk, while urging the need for more rigorous clinical studies to ensure patient safety.
Low foetal heart rate, a potentially ominous finding: case report.
Eur Heart J Case Rep
September 2024
Department of Cardiothoracic Pathology, University of Medicine and Pharmacy Carol Davila, 8 Eroii Sanitari Blv., Bucharest 050474, Romania.
Article Synopsis
- * A case of a 25-year-old pregnant woman highlighted the importance of cardiac evaluation after foetal bradycardia was detected; she was diagnosed with LQTS type 1, and managed with medication and monitoring, resulting in a safe delivery.
- * Early detection of foetal heart rate irregularities is critical in pregnancies, as persistent low heart rates can indicate LQTS and may require careful management strategies to ensure
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