AI Article Synopsis
- - C1q nephropathy was first described nearly 25 years ago, primarily focusing on pediatric cases, but there's still no agreed-upon definition for diagnosing it.
- - Reported occurrences in pediatric biopsy samples can reach up to 16%, raising questions about whether C1q nephropathy is its own distinct disease.
- - This review aims to explore how C1q functions biologically, examine existing pediatric case studies, clarify diagnostic criteria, and discuss long-term outcomes for affected children.
Article Abstract
C1q nephropathy was originally described nearly 25 years ago by Jennette and Hipp. Since that time there have been a limited number of publications on C1q nephropathy, most of them in the pediatric literature. Despite reported incidences as high as 16% in some pediatric biopsy series, a consensus definition on the diagnosis of C1q nephropathy is lacking and its existence as a distinct clinical disease entity remains controversial. The purpose of this review is to discuss the biology of C1q in the context of mechanisms of C1q deposition, and to provide a detailed analysis of the published pediatric case series with a focus on the pathological criteria used to establish the diagnosis of C1q nephropathy as well as long-term outcomes in children.
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| http://dx.doi.org/10.1007/s00467-009-1429-x | DOI Listing |
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