AI Article Synopsis
- Fluidic systems designed at the nanometre scale provide a sensitive approach for analyzing DNA molecules, allowing researchers to explore their properties in detail.
- These nanofluidic systems can sort DNA based on length and examine how DNA behaves in different environments.
- The review covers recent experiments using various nano-enabled fluidic platforms like nanochannels and nanopores, citing 161 references for in-depth research.
Article Abstract
Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules. Nanofluidic systems have been used to probe conformational, dynamic, and entropic properties of DNA molecules, to rapidly sort DNA molecules based on length dependent interactions with their confining environment, and for determining the spatial location of genetic information along long DNA molecules. In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references).
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| http://dx.doi.org/10.1039/b820266b | DOI Listing |
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