Modulating tumor vasculature through signaling inhibition to improve cytotoxic therapy.

Cancer Res

Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Published: March 2010

The tumor microenvironment is a key factor in cancer treatment response. Recent work has shown that changes in the tumor vasculature can be achieved by inhibiting tumor cell signaling, resulting in enhanced tumor oxygenation. These changes could promote responses to both chemo- and radiation therapy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840203PMC
http://dx.doi.org/10.1158/0008-5472.CAN-09-3615DOI Listing

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