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Background: Long QT Syndrome Type-2 (LQT2) is due to loss-of-function variants. encodes K 11.1 that forms a delayed-rectifier potassium channel in the brain and heart.
View Article and Find Full Text PDFEpilepsy and Cardiac Arrhythmias: A State-of-the-Art Review.
JACC Clin Electrophysiol
November 2024
Department of Cardiology, St Vincent's Hospital Melbourne, Fitzroy, VIC, Australia; Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Fitzroy, VIC, Australia; HEART Lab, St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia; HEART Lab, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. Electronic address: https://twitter.com/pretzeldr.
Epilepsy is an important cause of disability and mortality worldwide. It can be frequently misdiagnosed, and detailed history and relevant investigations are needed to differentiate epilepsy from syncope. Electroencephalogram is a key noninvasive assessment of neurological function, and the diagnostic yield is increased when performed for an extended period in the ambulatory setting with concurrent electrocardiogram and video monitoring.
View Article and Find Full Text PDF[Not Available].
Ugeskr Laeger
November 2024
Hjerteafdeling Y, Københavns Universitetshospital - Bispebjerg og Frederiksberg Hospital.
Article Synopsis
- * A case study is presented involving a 68-year-old woman with hippocampal sclerosis who experienced IA and mesial temporal lobe epilepsy.
- * There's limited evidence linking IB/IA to sudden unexpected death in epilepsy, and pacemaker treatment is not commonly used; the focus of care is primarily on reducing seizures and preventing falls.
Ictal asystole and increased ictal heart rate variability in PCDH19-related epilepsy.
Epileptic Disord
December 2024
Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Incidence and Types of Cardiac Arrhythmias in the Peri-Ictal Period in Patients Having a Generalized Convulsive Seizure.
Neurology
July 2024
From the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Article Synopsis
- The study aimed to investigate the occurrence of cardiac arrhythmias during generalized convulsive seizures (GCSs) and their potential link to sudden unexpected death in epilepsy (SUDEP).
- Researchers monitored adult epilepsy patients using video-EEG and various cardiological assessments to identify different types of arrhythmias occurring during seizures.
- The findings could provide insights into the relationship between seizure severity markers and cardiac arrhythmias, contributing to understanding the risk factors associated with SUDEP.
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