Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Highly prevalent geriatric medications and their effect on β-amyloid fibril formation.
BMC Neurol
November 2024
Corewell Health Research Institute, Corewell Health East, 3811 W 13 mile Road, Royal Oak, MI, 48073, USA.
Article Synopsis
- The study examines the impact of polypharmacy on dementia-related conditions, particularly focusing on Alzheimer’s disease, mild cognitive impairment, and non-demented individuals, revealing a high prevalence of polypharmacy among older adults.
- Researchers analyzed the medication profiles of 466 participants using statistical methods to categorize and quantify the frequency of drugs within ten major classes.
- Results showed a significant variety in prescriptions, such as anti-inflammatory and vitamin supplements, with 82-90% of the elderly population studied using multiple medications, but the effects on Aβ fibrils formation related to Alzheimer's remain unclear.
Nonvitamin K Anticoagulants: Risk of Bleeding When Interacting With Other Medications: A Cohort Study From Medicare.
Clin Cardiol
October 2024
Department of Pharmacotherapy, University of Utah, Salt Lake City, Utah, USA.
Introduction: Patients on nonvitamin K antagonist (NVKA) are usually taking other drugs. Potential interaction may increase the gastrointestinal (GI) bleeding risk associated with NVKA.
Methods: Observational cohort study using Medicare data from 2017 to 2020.
Adverse events in patients with cardiovascular disease taking proton pump inhibitors.
Expert Opin Drug Saf
November 2024
Servicio de Aparato Digestivo, Hospital Clínico Universitario, Zaragoza, Spain.
Introduction: Proton pump inhibitors (PPIs) rank among the most frequently prescribed medications to treat acid-related diseases. Mounting concerns surround the potential for serious adverse events, including cardiovascular events, associated with their prolonged use/misuse.
Areas Covered: This comprehensive review explores cardiovascular adverse events linked to PPI use among high-risk cardiovascular patients.
Prescribing practices for Proton pump inhibitors among primary care physicians in England.
BJGP Open
September 2024
Primary Care Society for Gastroenterology, Oxford, United Kingdom.
Background: Proton pump inhibitors (PPIs) the most frequently prescribed drug class globally, are often overused.
Aim: To assess PPI prescribing practice in England.
Design & Setting: Electronic medical record (EMR) evaluation from 62 primary care GP practices.
Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation.
BMC Med
August 2024
Department of Cardiology, Korea University Anam Hospital, Korea University College of Medicine, Cardiovascular Center 73, Goryeodae-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea.
Article Synopsis
- The study examined the effects of proton pump inhibitors (PPIs) on patients who underwent percutaneous coronary intervention (PCI) while taking clopidogrel for antiplatelet therapy, particularly focusing on their clinical outcomes and PRU levels.
- Among 13,160 patients, those using PPIs had higher PRU levels but did not show a significant increase in serious cardiovascular events when compared to non-users, with primary outcomes occurring in a similar proportion.
- However, for patients carrying certain genetic variations (CYP2C19 loss-of-function alleles), PPI use was associated with an increased risk of adverse outcomes, highlighting complex interactions between medication and genetics.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!