Aseptic meningitis is a benign condition often triggered by a virus or an immunological process. For example herpes virus, borrelia, tuberculosis, a fungus or an autoimmune disease may underlie meningitides presenting prolonged or recurrent symptoms. It is essential to identify the meningitis patients among the diverse group of headache patients and carry out focused investigations and treatment, and in mild cases to avoid complications caused by the investigations. Analgesic and antiemetic medication are usually sufficient for symptomatic treatment. Etiological treatment is available for some patients.
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New Microbes New Infect
December 2024
Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.
Adv Rheumatol
December 2024
Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Objectives: Describe tofacitinib safety from an integrated analysis of randomized controlled trials (RCTs) in patients with ankylosing spondylitis (AS).
Method: Pooled data from Phase 2 (NCT01786668; 04/2013-03/2015)/Phase 3 (NCT03502616; 06/2018-08/2020) RCTs in AS patients were analyzed (3 overlapping cohorts): 16-week placebo-controlled (tofacitinib 5 mg twice daily [BID] [n = 185]; placebo [n = 187]); 48-week only-tofacitinib 5 mg BID (n = 316); 48-week all-tofacitinib (≥ 1 dose of tofacitinib 2, 5, or 10 mg BID; n = 420). Baseline 10-year atherosclerotic cardiovascular disease (ASCVD) risk was determined in patients without history of ASCVD (48-week cohorts).
J Virol
December 2024
Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama, USA.
Unlabelled: Viral aseptic meningitis is a neuroinflammatory condition that occurs when viruses gain access to the central nervous system (CNS) and induce inflammation. The blood-brain barrier (BBB) is comprised of brain endothelial cells (BECs) that stringently regulate the passage of molecules, toxins, and pathogens from the circulation into the CNS. Through their unique properties, such as complex tight junctions, reduced rates of endocytosis, expression of efflux transporters, and restricted expression of leukocyte adhesion molecules, the BBB is often able to limit pathogen entry into the brain; however, certain neurotropic pathogens, such as coxsackievirus B3 (CVB3) are able to infect the CNS.
View Article and Find Full Text PDFJ Pak Med Assoc
December 2024
Department of Anaesthesiology, Aga Khan University Hospital, Karachi, Pakistan.
In an immunocompetent person, varicella zoster virus (VZV) is an uncommon cause of aseptic meningoencephalitis. Reactivation of the latent varicella zoster virus from nerve infection results in shingles, a condition marked by rash, intense pain, and dermal involvement in immunocompromised hosts. We present an unusual case of a 22-year-old immunocompetent male diagnosed as VZV meningoencephalitis without exanthem.
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