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and Gene Variants in Women with Early Pregnancy Losses from North Macedonia.
Balkan J Med Genet
June 2024
Research Center for Genetic Engineering and Biotechnology "Georgi D. Efremov", Macedonian Academy of Sciences and Arts, Skopje, North Macedonia.
Article Synopsis
- Early pregnancy loss (EPL) occurs in about 15% of recognized pregnancies, and around 50% of the cases don't have a clearly defined cause, termed idiopathic.
- The study investigated the association of genetic variants in particular genes among women in North Macedonia with EPL, compared to a control group of women without pregnancy loss.
- Findings indicated a significant prevalence of heterozygotes for certain genetic haplotypes in women with EPL, supporting previous research on the connection between these haplotypes and pregnancy loss and demonstrating a cost-effective genotyping method.
Use of anticoagulants to improve pregnancy outcomes in couples positive for M2 haplotype: A systematic review.
Eur J Obstet Gynecol Reprod Biol
May 2024
Queen's University Belfast, University Road, Belfast BT7 1NN, Northern Ireland, UK.
Background: Placental mediated pregnancy complications (PMPC) are common, often recurring, and pose a significant health risk to mother and fetus. Evidence suggests that the hypercoagulable state associated with many PMPC, could reflect reduced expression of Annexin 5 (ANXA5), a naturally occurring anticoagulant protein in placental tissue. The ANXA5 M2 haplotype is a genetic variant, which results in reduced expression of ANXA5 protein.
View Article and Find Full Text PDFResearch progress on ANXA5 in recurrent pregnancy loss.
J Reprod Immunol
September 2022
Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal and Fetal Medicine, Shanghai First Maternity & Infant Hospital, Shanghai 201204, China. Electronic address:
The incidence of recurrent pregnancy loss (RPL) in fertile women ranges from 1% to 5%, of which about 50% of them are due to unknown causes. The possible pathogenesis of RPL is an urgent problem to be solved in the clinical. Mutations or polymorphisms of certain genes in the coagulation mechanism are associated with susceptibility to thrombotic diseases and are one of the main reasons for the occurrence of RPL.
View Article and Find Full Text PDFAssociation between ANXA5 haplotypes and the risk of recurrent pregnancy loss.
J Int Med Res
July 2022
Department of Obstetrics and Gynecology, The First People's Hospital of Wenling Affiliated to Wenzhou Medical University, Wenling, Zhejiang, China.
Background: Annexin A5 (ANXA5) haplotypes can increase the risk of recurrent pregnancy loss (RPL). This study aimed to investigate the effect of ANXA5 haplotypes on ANXA5 expression in patients with RPL.
Methods: Female subjects with RPL, parous controls (those who intentionally aborted without medical conditions or complications), and population controls (normal delivery) were studied.
Genetic markers for inherited thrombophilia related pregnancy loss and implantation failure in Indian population - implications for diagnosis and clinical management.
J Matern Fetal Neonatal Med
December 2022
Fertility Genomics Division, GeneTech, Hyderabad, India.
Aim: The biology of recurrent pregnancy loss and recurrent implantation failure (RPL-RIF) is complex with multi-factorial etiology, with defective thrombosis being one of the most important and highly prevalent causes. The role of several thrombophilia related genes and variants associated with RPL-RIF is widely reported, and this study aimed to identify the risk associated with these genes in the Indian population.
Methods: Next generation sequencing (NGS) was employed for the current study.
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