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Pharmacological Strategies for Postdischarge Nausea and Vomiting: Evidence-based Review Update.
J Perianesth Nurs
December 2024
Graduate Programs of Nurse Anesthesia, Texas Wesleyan University, Fort Worth, TX.
Purpose: Evaluate the effectiveness of various drugs in preventing postdischarge nausea and vomiting (PDNV).
Design: Systematic review.
Methods: A search for evidence was conducted in PubMed, CINAHL, Cochrane Collaboration, and Google Scholar and gray literature.
Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a systematic review and meta-analysis.
J Minim Invasive Surg
December 2024
Department of Community Medicine, ESIC Medical College and Hospital, Chennai, India.
Purpose: Postoperative nausea and vomiting (PONV) is a prevalent and distressing complication, especially in laparoscopic surgeries. This review compares the efficacy and safety of palonosetron and ondansetron in preventing PONV after laparoscopic surgery.
Methods: A systematic review was conducted in PubMed, Google Scholar, Semantic Scholar, and Cochrane Library to identify comparative studies that reported the efficacy (nausea and vomiting) at three postoperative time points T1 (0-2 hours), T2 (2-6 hours), T3 (6-24 hours) and safety (incidence of adverse effects).
Randomized, Phase III Trial of Mixed Formulation of Fosrolapitant and Palonosetron (HR20013) in Preventing Cisplatin-Based Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: PROFIT.
J Clin Oncol
December 2024
Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Purpose: Mixed formulation of fosrolapitant and palonosetron (PALO), HR20013, is a novel fixed-dose intravenous antiemetic combination that could simultaneously antagonize neurokinin-1 and 5-hydroxytryptamine-3 receptors. This study was designed to evaluate the efficacy and safety of HR20013 plus dexamethasone (DEX) versus fosaprepitant (FAPR) plus PALO + DEX for preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC).
Methods: This is a noninferiority study.
Comparative Efficacy of Novel Versus Traditional Antiemetic Agents in Preventing Chemotherapy-Induced Nausea and Vomiting With Moderate or Highly Emetogenic Chemotherapy: A Systematic Review.
Cureus
October 2024
Department of Internal Medicine, Allama Iqbal Medical College, Lahore, PAK.
Article Synopsis
- The review analyzes the effectiveness of new antiemetic medications versus traditional ones for preventing chemotherapy-induced nausea and vomiting (CINV) in patients undergoing moderate or highly emetogenic chemotherapy.
- It finds that novel agents like netupitant/palonosetron and olanzapine are at least as effective, if not better, than standard antiemetic treatments that use aprepitant and other agents.
- The study calls for more direct comparisons and larger trials to further understand the benefits of these new therapies in everyday clinical practice.
A Comparative Study on the Efficacy of Intravenous Palonosetron Versus a Combination of Ondansetron and Dexamethasone as Prophylaxis for Prevention of Postoperative Nausea and Vomiting After Laparoscopic Surgeries.
Cureus
October 2024
Department of Anaesthesiology and Critical Care, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, IND.
Background: The most troublesome complaint after general anaesthesia and surgery, especially laparoscopic surgeries, is postoperative nausea and vomiting (PONV). We routinely use pharmacologic prophylaxis to prevent PONV. In patients undergoing laparoscopic procedures, we assessed the effectiveness of palonosetron compared to ondansetron combined with dexamethasone in preventing the incidence of PONV.
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