AI Article Synopsis
- The study investigated the connection between fatty degeneration in thigh muscles and vitamin D levels in older adults aged 65 and older.
- In a six-month evaluation of 121 patients, 20 underwent MRI to assess muscle changes, revealing varying levels of degeneration and a significant negative correlation between fatty degeneration and both vitamin D levels and balance/gait scores.
- The findings suggest that vitamin D deficiency contributes to muscle degeneration and affects balance and gait, highlighting the importance of maintaining adequate vitamin D levels in the elderly.
Article Abstract
Objective: The purpose of this study was to study the relationship between fatty degeneration of thigh muscles and vitamin D status in elderly adults.
Subjects And Methods: For six months, 121 patients 65 years old or older were evaluated. Myopathy, muscular impairment, and conditions influencing vitamin D status other than diet and sunlight were exclusion criteria. Twenty patients (10 men and 10 women; mean age, 77.6 years) underwent MRI. Thigh muscles were scanned from the hip to the knee with T1- and T2-weighted spin-echo sequences. Skeletal muscles were evaluated for fatty degeneration and atrophy from grade 0 to 3 (grade 0 = normal appearance, grade 3 = severe changes). The relationship between muscular fatty degeneration, 25-hydroxyvitamin D (25-OHD) levels, and scores on Tinetti scales for balance and gait were examined.
Results: In the evaluation of the extensor muscles for fatty degeneration and atrophy, grade 0 was present in three patients (15%), grade 1 in 11 (55%), and grade 2 in six (30%). In the flexor muscles, grade 0 was found in one patient (5%), grade 1 in five (25%), and grade 2 in 14 (70%); grade 3 changes were not seen. Muscular fatty degeneration negatively correlated with 25-OHD levels (r = -0.50, p < 0.01) and the Tinetti scores (balance: r = -0.40, p < 0.05; gait: r = -0.50, p < 0.05). In 11 vitamin D-deficient patients (55%), there was selective complete atrophy of at least one thigh muscle. The gracilis and sartorius muscles were spared.
Conclusion: In elderly adults, fatty degeneration of thigh muscles was associated with vitamin D deficiency and impaired balance and gait. Selective complete fatty degeneration of single muscles was observed.
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| http://dx.doi.org/10.2214/AJR.09.3130 | DOI Listing |
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