Water-soluble [60]fullerene (C(60)) derivatives were synthesized to examine their bioactivities. PC12 cells were used as a model of nerve cells and the bioactivities of synthesized C(60) derivatives together with some reported ones were tested. Among the compounds tested, C(60)/(gamma-CyD)(2), C(60)-bis(gamma-CyD) (5) containing C(60)-mono(gamma-CyD) (5'), and C(60)/PVP were sufficiently soluble in water and showed an enhancing effect on the neurite outgrowth of NGF-treated PC12 cells.
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| http://dx.doi.org/10.1016/j.bmcl.2010.01.142 | DOI Listing |
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