Indication and technical requirements analyses for custom made THR have been made. Indications for the use of custom made THR and the results achieved have been assessed according to the available literature and compared to the results of standard THR. There is a significant divergence in indications, late results and production costs. Clinical reports focus mostly on individual project metric data preparation method, technical aspects (such as shape or used material) or implantation method. Biomechanical analysis of achievable range of motion, ways of load transportation and equalization of frequently substantial discrepancy in leg length, is more hypothetical. The difficulty stems from the soft tissue quality which cannot be determined precisely, the cause of contracture or dynamic dysfunction triggered by the change of muscle action axis and muscle force over the joint, after changes of offset and joint axis of motion. In complicated cases, preoperative planning of a single approach/solution strategy can pose severe difficulties which would be hard to overcome during operation. Analysis was based on 2 cases.
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Biol Trace Elem Res
January 2025
Department of Nutrition and Metabolism, Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing, 100050, China.
Selenium (Se) intake or selenoprotein overexpression can cause abnormal glucose metabolism and increase the risk of type 2 diabetes (T2D). The purpose of this study is to observe whether glycolysis bypass in the de novo serine synthesis pathway (SSP) is activated under high-Se stress in vitro. Initially, HCT-116, L02, HepG2, and differentiated C2C12 cells were exposed to five selenomethionine (SeMet) concentrations (0.
View Article and Find Full Text PDFAmino Acids
December 2024
Department of Gastroenterology and Hepatology, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
Little is known about how blood free amino acids (FAAs) change in metabolic dysfunction-associated steatotic liver disease (MASLD). This study aims to identify the imbalance of FAAs in MASLD and explore its correction as a potential therapeutic target. We analyzed plasma FAAs data from 23,036 individuals with steatosis information from a biobank in Japan, and 310 patients with MASLD were enrolled.
View Article and Find Full Text PDFJ Clin Orthop Trauma
December 2024
Trauma & Orthopaedics Department, Kettering General Hospital NHS Foundation Trust, NN16 8UZ, UK.
Introduction: In the rapidly evolving landscape of digital health technologies, the widespread use of smartphones has paved the way for innovative applications designed to enhance healthcare experiences. This introduction underscores the global prevalence of smartphone users and their potential in healthcare, particularly exemplified by therapeutic apps such as the 'Post Op' smartphone application. Focused on postoperative support, this app prioritises user-friendly design, data recording, and adherence to national standards.
View Article and Find Full Text PDFAnaerobe
December 2024
Graduate School of Veterinary Science, Osaka Metropolitan University, 1-58 Rinku Ourai Kita, Izumisano, Osaka, 598-8531, Japan; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, 1-58 Rinku Ourai Kita, Izumisano, Osaka, 598-8531, Japan; Research Center for Food Safety, Osaka Metropolitan University, 1-58 Rinku Ourai Kita, Izumisano, Osaka, 598-8531, Japan.
Objectives: Although Clostridium perfringens sporulation is a key event in the pathogenesis of food-borne illness, the molecules and underlying mechanisms responsible for regulating sporulation are incompletely understood. The present study sought to identify amino acids that affect sporulation in C. perfringens strain SM101.
View Article and Find Full Text PDFJ Clin Orthop Trauma
September 2024
Department of Orthopaedic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
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