AI Article Synopsis
- The lack of oxygen (hypoxia) in solid tumors helps cancer cells survive and avoid treatments.
- Researchers found that hypoxia makes tumor cells grow and stay alive by using a special protein called Egr-1.
- Reducing Egr-1 made the tumor cells more sensitive to treatment, showing a new way to make cancer therapies work better against these cells.
Article Abstract
The hypoxic environment of solid tumor causes the tumor cells survive and which could protect them from death by facilitating resistance to therapy. Here, we provide evidence that hypoxia can increase tumor cell viability and proliferation through an Egr-1-dependant pathway. Hypoxia protected the microtubules from disassembly, and Egr-1 was colocalized with microtubules in different cell cycle stages. Knockdown of Egr-1 with its siRNA overcame the protection effect of hypoxia and increased the sensitivity of tumor cells to vinblastine under hypoxic conditions. Our results suggest a novel approach for increasing the sensitivity of tumor cells to chemotherapeutics that target microtubule assembly.
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| http://dx.doi.org/10.1002/ar.21086 | DOI Listing |
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