AI Article Synopsis
- There is no agreement on the best antiviral treatment for acute retinal necrosis caused by herpetic viruses, as most guidelines are based on retrospective studies rather than randomized trials.
- The incidence of this disease is low, making comprehensive clinical studies challenging, but newer oral antivirals may provide easier outpatient options compared to traditional high-dose intravenous acyclovir.
- While drug resistance is rare, it can be hard to detect, and caution is advised when prescribing antivirals to patients with kidney issues, pregnant women, or those with weakened immune systems.
Article Abstract
There is no consensus on the optimal antiviral regimen in the management of acute retinal necrosis, a disease caused by herpetic viruses with devastating consequences for the eye. The current gold standard is based on retrospective case series. Because the incidence of disease is low, few well-designed, randomized trials have evaluated treatment dosage and duration. Newer oral antiviral agents are emerging as alternatives to high-dose intravenous acyclovir, avoiding the need for inpatient intravenous treatment. Drug resistance is uncommon but may also be difficult to identify. Antiviral drugs have few side effects, but special attention needs to be paid to patients who have underlying renal disease, are pregnant or are immunocompromised.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819764 | PMC |
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