Valgus producing high tibial osteotomy (HTO) is an effective treatment option for medial compartment osteoarthrosis with varus deformity in young patients. The most common complications of conventional high tibial osteotomy techniques are related to accuracy of correction. Major angle correction of more than 15 degrees with an osteotomy proximal to the tibial tuberosity may cause significant change in patellofemoral mechanics and patellar height. Valgus HTO was performed in 11 lower limbs of 9 patients with gradual correction of the varus deformity using an Ilizarov external fixator, with the osteotomy at the distal border of the tibial tuberosity. The mean age of the patients was 38.5 years. The average correction was 17 degrees. They were followed up for an average of 25 months. The mean preoperative "Hospital for Special Surgery" (HSS) score was 68 and improved to a mean of 90 at follow-up. Nine limbs had excellent or good HSS scores. Disadvantages of this technique were mainly pin tract infection and poor patient acceptance and noncompliance.
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J Cyst Fibros
January 2025
INSERM U1151, Institut Necker Enfants Malades, Paris, France; Hôpital Necker Enfants Malades, Centre de Référence Maladies Rares Mucoviscidose et Maladies apparentées, Paris, France; Université Paris-Cité, Paris, France; European Reference Network-Lung. Frankfurt, Germany. Electronic address:
Background: The triple combination Elexacaftor/Tezacaftor/Ivacaftor (ETI) translates into major respiratory improvements in adults; yet current clinical endpoints may prove insufficiently sensitive in young children. We hypothesised that ETI rapidly modifies the lungs' metabolism, resulting in changes in breath composition.
Methods: Eleven children with CF were enrolled in a longitudinal pilot study at the paediatric Necker hospital.
Knee Surg Sports Traumatol Arthrosc
January 2025
Department of Trauma, Hand and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany.
Purpose: The medial collateral ligament (MCL), and posterior oblique ligament (POL) are the primary valgus stabilisers of the knee, and clinical examinations in grading valgus instability can be inherently subjective. Stress radiography of medial-sided knee injuries provides objective diagnosis and was analysed in this study. We hypothesised that (1) medial joint space opening would increase cutting the superficial MCL (sMCL), POL and anterior cruciate ligament (ACL); (2) isolated deep MCL (dMCL) injury would not increase medial joint space opening; (3) medial joint space opening would increase at higher flexion angles.
View Article and Find Full Text PDFCommun Med (Lond)
January 2025
Department of Human Genetics, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.
Background: Stargardt disease type 1 (STGD1) is a progressive retinal disorder caused by bi-allelic variants in the ABCA4 gene. A recurrent variant at the exon-intron junction of exon 6, c.768G>T, causes a 35-nt elongation of exon 6 that leads to premature termination of protein synthesis.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
December 2024
Department of Ophthalmology, University of Tokyo Hospital, 7-3-1, Bunkyo-ku, Tokyo, Japan.
Purpose: This report presents a case of fungal keratitis treated with penetrating keratoplasty using a cryopreserved cornea, highlighting the successful maintenance of corneal transparency post infection resolution.
Observations: A 57-year-old man complaining of pain in the right eye was referred to our hospital. Although diagnosed with fungal keratitis, his corneal scraping indicated the presence of , and he was unresponsive to voriconazole, micafungin, and pimaricin treatments.
Global Spine J
January 2025
Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.
Study Design: Retrospective cohort study.
Objective: To analyze the efficacy and safety of Halo-femoral traction (HFT) following spinal release, and preoperative Halo-gravity traction (HGT) in patients with severe spinal kyphoscoliosis and spinal cord risk classification (SCRC) type 3 at the apex.
Methods: A total of 73 patients (24 males, 49 females, mean age 22.
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