AI Article Synopsis
- A 59-year-old woman with idiopathic insulin autoimmune syndrome experiences high insulin levels and antibodies without prior insulin use, causing hypoglycemia.
- Early spikes in glucose followed by late drops are due to antibodies affecting insulin action.
- Correct diagnosis is crucial to prevent unnecessary procedures, with conservative treatment focused on managing carbohydrate intake throughout the day leading to a good prognosis.
Article Abstract
We report the case of a 59-year-old women with idiopathic insulin auto-immune syndrome, a rare cause of endogenous hyperinsulinemic hypoglycemia. It is characterized by extremely high levels of insulin in the presence of high titers of insulin antibodies despite the absence of previous insulin injections. Early postprandial increase in glucose concentrations due to impaired insulin action resulting from the buffering effect of the antibodies and late postprandial hypoglycemia as a consequence of the dissociation of insulin from the antibodies was observed. A correct diagnosis is important to avoid unnecessary investigations and surgery in these patients who are best treated conservatively - with a good prognosis - by fractionating carbohydrate intake during the day.
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| http://dx.doi.org/10.1024/1661-8157/a000037 | DOI Listing |
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