AI Article Synopsis
- A study involving 415 Alzheimer's disease (AD) patients aged 65 and older explored how vascular risk factors influence the progression of the disease over five years.
- Results showed that AD patients with vascular risks, such as hypertension and diabetes, experienced a faster decline in cognitive and functional abilities compared to those without these risks.
- The findings indicate that managing vascular risk could potentially slow down the progression of Alzheimer's disease, suggesting a link between vascular health and the severity of AD.
Article Abstract
To investigate whether vascular risk affects the progression of Alzheimer's disease (AD), 415 AD patients aged 65 years old and over without cerebrovascular diseases were enrolled and administered with a structured interview to assess demography, vascular risk factors, and cognitive and functional status at baseline, and 324 AD patients were followed up annually for 5 years. A mixed random effects regression model was used to identify the association between vascular risk, individual vascular risk factors, and the progression of AD. After adjusting for confounding factors, AD patients with vascular risk had faster cognitive and functional decline rates than the subjects without such risk factors. Individual vascular risk factors including hypertension and diabetes mellitus, transient ischemic attack and cerebrovascular accident during the follow-up were independently associated with the progression of AD. Our findings suggest that vascular risk aggravates the progression of AD and may be involved in the etiologic process of AD. As such, control of vascular risk may slow down the progression of AD.
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| http://dx.doi.org/10.3233/JAD-2010-1383 | DOI Listing |
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