Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816554 | PMC |
| http://dx.doi.org/10.4314/ajtcam.v5i3.31281 | DOI Listing |
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