AI Article Synopsis
- - The indole-diketopiperazine bridge is a key structural element found in various fungal metabolites, specifically bispyrrolidinoindolines and epipolythiodiketopiperazines.
- - Researchers successfully used organocatalytic conjugate addition to combine diketopiperazines with indoles, resulting in high yields via electrophilic indolenine intermediates.
- - The study involved testing different catalysts and solvents at varying temperatures to optimize product yields.
Article Abstract
The indole-diketopiperazine bridge is an important structural feature of many bispyrrolidinoindoline and epipolythiodiketopiperazine fungal metabolites. Organocatalytic conjugate addition of diketopiperazines to indoles was achieved in good to excellent yields through electrophilic indolenine intermediates generated under mild conditions. Screening of catalysts and solvents at different temperatures was performed in order to achieve high product yields.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805156 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2009.11.068 | DOI Listing |
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