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A New Paradigm for Protein Design and Biological Self-Assembly. | LitMetric

A New Paradigm for Protein Design and Biological Self-Assembly.

J Fluor Chem

Department of Chemistry, Tufts University, Medford, MA 02155.

Published: December 2009

AI Article Synopsis

Article Abstract

Very few molecules with biological origins contain the element fluorine. Nature's inability to incorporate fluorine into biomolecules is related to the low concentration of free fluoride in sea and surface water. However, judicious introduction of fluorine into proteins, nucleic acids, lipids and carbohydrates has allowed mechanistic scrutiny of enzyme catalysis, control of protein oligomerization in membranes, clustered display of ligands on surfaces of living cells, and in increasing the protease stability of protein and peptide therapeutics.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786179PMC
http://dx.doi.org/10.1016/j.jfluchem.2009.09.002DOI Listing

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