AI Article Synopsis
- Recent evidence supports the theory that microbes, specifically Novosphingobium aromaticivorans, may trigger autoimmune diseases, particularly primary biliary cirrhosis (PBC).
- A mouse model showed that infection with Novosphingobium resulted in liver damage similar to PBC and led to the production of antibodies that cross-react with the bacterium.
- This finding could transform our understanding of autoimmune diseases' causes and lead to new diagnostics and treatments.
Article Abstract
Despite having long been postulated, compelling evidence for the theory that microbial triggers drive autoimmunity has only recently been reported. A specific association between Novosphingobium aromaticivorans, an ubiquitous alphaproteobacterium, and primary biliary cirrhosis (PBC) has been uncovered in patients with PBC. Notably, the association between Novosphingobium infection and PBC has been confirmed in a mouse model in which infection leads to the development of liver lesions resembling PBC concomitant with the production of anti-PDC-E2 antibodies that cross-react with conserved PDC-E2 epitopes shared by Novosphingobium. The discovery of infectious triggers of autoimmunity is likely to change our current concepts about the etiology of various autoimmune syndromes and may suggest new and simpler ways to diagnose and treat these debilitating diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742979 | PMC |
| http://dx.doi.org/10.1586/ECI.09.23 | DOI Listing |
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