The transition of a cell from one state to another involves large changes in the organization of its chromatin. Indeed, it has become increasingly clear that modifications of the chromatin are the molecular basis of an epigenetic memory that defines cellular identity. Histone variants are likely candidates to contribute to epigenetic regulations. Genome-wide profiling of the unusual macroH2A histone variants and the identification of interacting proteins provided important clues to their molecular and physiological function.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4161/epi.5.2.11076 | DOI Listing |
Publication Analysis
Top Keywords
molecular physiological
8
physiological function
8
histone variants
8
approaching molecular
4
function macroh2a
4
macroh2a variants
4
variants transition
4
transition cell
4
cell state
4
state involves
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!