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Role of centchroman in regression of fibroadenoma: A 2-arm randomized control trial.
Clinics (Sao Paulo)
December 2024
Department of General Surgery, Dr. RMLIMS, Lucknow, Uttar Pradesh, India.
Background: Fibroadenomas are common benign breast lumps that can cause anxiety due to malignancy concerns, and Centchroman, a selective estrogen receptor modulator, has shown promise in reducing their size. This study aimed to evaluate the efficacy of Centchroman in reducing fibroadenoma size, mastalgia, anxiety, and depression in affected patients.
Methodology: A parallel-arm randomized controlled trial was conducted at a tertiary care Breast Clinic with 104 patients aged 18‒45 years having fibroadenomas ≤ 3 cm.
The Usefulness of Exosomes in Accelerating Healing and Preventing Complications in Behçet's Disease: A Case Report.
Cureus
November 2024
Gynecology, CosmeSurge Group, Dubai, ARE.
Behçet's disease (BD) is a systemic auto-inflammatory vasculitis. The clinical pictures of BD involve the skin and mucosal membranes such as oral and genital ulcers, ocular lesions, cardiovascular, gastrointestinal, muscular, nervous systems, and joints. A 38-year-old woman was repeatedly suffering from oral, genital, and ocular lesions, wound dehiscence after any surgical procedure, and joint pain.
View Article and Find Full Text PDFBIOFILLER VS PLATELET-RICH PLASMA MESOTHERAPY IN THE TREATMENT OF PERI-ORBITAL HYPERPIGMENTATION.
J Ayub Med Coll Abbottabad
November 2024
Pak Emirates Military Hospital, Rawalpindi-Pakistan.
Article Synopsis
- Peri orbital hyperpigmentation (POH) is a common skin issue with various causes, and this study aimed to compare the effectiveness of Biofillers vs. Platelet-Rich Plasma (PRP) therapy in treating it.
- In a double-blinded randomized trial involving 42 patients, the results showed that Biofillers provided significant improvements in pigmentation, patient satisfaction, and had fewer side effects compared to PRP.
- The study concluded that Biofillers are a more effective and safer treatment option for POH than PRP therapy.
Equity and Outcome Events in Hidradenitis Suppurativa: Exploring Effect Modifiers Associated with Diagnostic Delay in the Real World.
Dermatol Ther (Heidelb)
December 2024
Novartis Pharma AG, Basel, Switzerland.
Introduction: Patients with hidradenitis suppurativa (HS) experience significantly delayed diagnoses of 7-10 years from symptom onset on average, but the reasons for this remain largely unknown. This study investigated drivers of diagnostic delay from the perspective of healthcare system equity.
Methods: A literature review was performed to identify published factors associated with delayed HS diagnosis to inform data analysis.
Paediatric Langerhans cell histiocytosis with diabetes insipidus: remarkable recovery journey.
J Pak Med Assoc
October 2024
Department of Paediatric Medicine, National Institute of Child Health, Karachi, Pakistan.
Article Synopsis
- - Langerhans cell histiocytosis (LCH) is a rare immune condition characterized by the abnormal growth of Langerhans cells, affecting various parts of the body and leading to a wide range of symptoms.
- - A case study of a four-year-old boy showed symptoms like a scalp rash, lumps on his head, and polyuria (excessive urination) over a few months.
- - After thorough investigations, the boy was diagnosed with LCH, which also caused central diabetes insipidus as a complication.
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