AI Article Synopsis
- The study explored the relationship between prenatal stress and the development of infantile spasms in 120 infants, comprising 60 cases and two control groups.
- The researchers found no significant differences in the causes of infantile spasms compared to other epilepsy cases but did identify higher levels of prenatal stress among mothers of infants with spasms.
- Regression analysis indicated that increased maternal prenatal stress was linked to a higher risk of infantile spasms, particularly for lower levels of stress.
Article Abstract
The present study investigated a possible correlation between prenatal stress and the onset of infantile spasms. A total of 120 infants (60 cases, 30 positive controls, and 30 negative controls) went through routine etiologic screening. The Pregnant Woman Life Event Scale was used to investigate and evaluate the degree of prenatal stress of the mothers in the three infant groups. Etiologic analyses indicated no statistical difference between the infantile spasms group and the other epilepsy control group. There was a significant difference in the degree of prenatal stress among mothers of the three infant groups, with higher maternal prenatal stress levels in the infantile spasms group than in the other epilepsy group (positive control) or the normal control group (P < 0.05). Regression analysis with the dummy variable indicated that the onset risk of infantile spasms correspondingly increased with the degree of maternal prenatal stress for stress levels 1-3 (out of four levels) (P < 0.05). Within a certain range, the onset risk of infantile spasms increases with the degree of prenatal stress.
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| http://dx.doi.org/10.1016/j.pediatrneurol.2009.09.003 | DOI Listing |
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