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[Cutaneous T-cell lymphomas].
Bull Cancer
November 2024
Service de dermatologie et oncologie cutanée, centre hospitalier Estaing, CHU de Clermont-Ferrand, université Clermont-Auvergne, place Lucie-Aubrac, 63000 Clermont-Ferrand, France. Electronic address:
Article Synopsis
- Primitive cutaneous T-cell lymphomas are skin-specific lymphomas, distinct from systemic lymphomas affecting the skin.
- The most common types include mycosis fungoides, CD30+ lymphoproliferations, and erythrodermic T-cell lymphomas, with several rarer forms also identified.
- Diagnosis relies on clinical skin exams and biopsies, enhanced by molecular genetics, while treatments are categorized into five main types, including skin therapies and immunotherapies.
Clinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas.
Cancers (Basel)
September 2024
Department of Dermatology, Yale School of Medicine, New Haven, CT 06510, USA.
Article Synopsis
- The text discusses the classification of Cutaneous T-cell Lymphomas (CTCL), highlighting the prevalence of CD4+ T-helper cell variants and a spectrum of CD8+ variants with various clinical and histological features.
- CD8 and cytotoxic molecules can be identified through immunohistochemical staining, but their presence alone is not enough for diagnosis or determining prognosis.
- The review covers specific CTCL subtypes that express CD8 positivity, including mycosis fungoides, lymphomatoid papulosis, and aggressive forms, underscoring the importance of combining clinical, histologic, and immunohistochemical data for accurate diagnosis and treatment.
Localized lymphomatoid papulosis: Unilesional lymphomatoid papulosis, regional lymphomatoid papulosis, and persistent agmination of lymphomatoid papulosis.
Clin Dermatol
December 2022
Department of Dermatology, Brown University Alpert School of Medicine, Providence, Rhode Island, USA.
Lymphomatoid papulosis (LYP), the most common primary cutaneous CD30-positive lymphoproliferative disorder, is heralded by multiple papular and nodular lesions at anatomically discontiguous cutaneous sites. The histologic patterns are protean. An uncommon form of LYP is one that is anatomically confined.
View Article and Find Full Text PDFPrimary cutaneous CD8+ cytotoxic T-cell lymphoma of the face with intraoral involvement, resulting in facial nerve palsy after chemotherapy.
J Cutan Pathol
June 2022
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, Brazil.
Article Synopsis
- * It presents a case study of a 33-year-old man who developed progressive facial swelling and lower lip involvement, with specific microscopic findings leading to a diagnosis of PC peripheral T-cell lymphoma, NOS (PTCL-NOS).
- * After chemotherapy, the patient experienced complications, including facial nerve palsy, emphasizing the need to consider CD8+ T-cell LPDs when evaluating similar symptoms like facial swelling and oral involvement.
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