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End-user feedback early in product development is important for optimizing multipurpose prevention technologies for HIV and pregnancy prevention. We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days compared to a dapivirine-only ring (DVR-200mg) in MTN-030/IPM 041 (n = 23), and when used for 90 days cyclically or continuously in MTN-044/IPM 053/CCN019 (n = 25). We enrolled healthy, non-pregnant, HIV-negative women aged 18-45 in Pittsburgh, PA and Birmingham, AL (MTN-030 only).

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Background: On demand, topical PrEP is desired by those preferring episodic, nonsystemic PrEP. PC-1005 gel (MIV-150, zinc, and carrageenan) exhibits in vitro antiviral HIV-1, human papillomavirus (HPV), and herpes simplex virus type 2 (HSV-2) activity, attractive for a multipurpose prevention technology candidate. We evaluated the safety, pharmacokinetics, and antiviral effect of rectally applied PC-1005.

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Inappropriate, excessive, or overly strenuous training of sport horses can result in long-term injury, including the premature cessation of a horse's sporting career. As a countermeasure, this study demonstrates the easy implementation of a biomechanical load monitoring system consisting of five commercial, multi-purpose inertial sensor units non-invasively attached to the horse's distal limbs and trunk. From the data obtained, specific parameters for evaluating gait and limb loads are derived, providing the basis for objective exercise load management and successful injury prevention.

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Coating Agents for Resin Composites: Effect on Color Stability, Roughness, and Surface Micromorphology Subjected to Brushing Wear.

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*Roberta Tarkany Basting, DDS, MSc, PhD, Professor, Restorative Dentistry Department, Faculdade São Leopoldo Mandic, São Paulo, Brazil.

This study evaluated the influence of six resin composite coating agents on color stability and surface roughness after toothbrushing abrasion. Discs (Ø6 mm x 2 mm) of nanofilled resin composite (Filtek Z350XT) were prepared for application of coating agents (n=10): control (absence), two surface sealants (PermaSeal and BisCover LV), two adhesive systems (Scotchbond Multi-Purpose Adhesive/3M Oral Care and Single Bond Universal), and two modeling liquids (Modeling Resin and Composite Wetting Resin). CIELab*, WID, and color change (ΔEab, ΔE00, and ΔWID) were analyzed at baseline, after finishing and polishing, after application of coating agents, after coffee staining (simulating 30 days and one year of staining), and after toothbrushing abrasion.

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D-peptide hydrogels as a long-acting multipurpose drug delivery platform for combined contraception and HIV prevention.

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School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, Northern Ireland BT9 7BL, United Kingdom. Electronic address:

Article Synopsis
  • New multipurpose prevention technologies for women prioritize reducing HIV risks and preventing unwanted pregnancies, promoting greater sexual health choices.
  • A novel long-acting injectable platform combines the HIV drug MIV-150 and the contraceptive etonogestrel using a specially designed D-peptide that forms a drug-releasing hydrogel after injection.
  • The technology shows promising biostability, low toxicity, and sustained delivery of both drugs in animal models for nearly 50 days, indicating its potential for effective long-term use.
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