Objectives: To investigate the effect of various medications on vitamin B12 status and the association between vitamin B12 levels and mortality.
Design: Retrospective cross-sectional study.
Setting: Four internal medicine departments and the geriatrics department at Kaplan Medical Center (KMC), Rehovot and Harzfeld Geriatrics Hospital, Gedera, Israel.
Participants: One thousand five hundred seventy patients aged 65 and older hospitalized at the KMC and Hartzfeld Hospital in 2007.
Measurements: Blood vitamin B12 levels and demographic, clinical, and laboratory data obtained from electronic medical records.
Results: Vitamin B12 deficiency (
Conclusion: Higher vitamin B12 levels were associated with greater mortality, but it is unclear whether vitamin B12 is a marker or a surrogate marker or even a substance that directly causes death. Further investigation is needed to clarify.
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