AI Article Synopsis
- The study tested the antimycobacterial activity of several compounds derived from cubebin and hinokinin against different strains of Mycobacterium, including M. tuberculosis, M. kansasii, and M. avium.
- Among these, hinokinin (2) had a minimum inhibitory concentration (MIC) of 62.5 microg/mL against M. tuberculosis, while derivatives (-)-O-acetyl-cubebin (3) and (-)-O-methyl-cubebin (4) showed 62.5 and 31.25 microg/mL MIC values against M. avium, respectively.
- Notably, all tested compounds were ineffective against M. kansasii, but the
Article Abstract
The antimycobacterial activity of (-)-cubebin (1), hinokinin (2), and some of their semisynthetic derivatives, namely (-)-O-acetyl-cubebin (3), (-)-O-methyl-cubebin (4), (-)-O-(N,N-dimethylamine-ethyl)-cubebin (5) and (-)-6,6'-dinitrohinokinin (6), was evaluated against Mycobacterium tuberculosis (ATCC 27294), M. kansasii (ATCC 12478), and M. avium (ATCC 15769). The MIC values ranged from 31.25 to 2000 microg/mL. Among the evaluated compounds, 2 displayed a MIC value of 62.5 microg/mL against M. tuberculosis, while 3 and 4 displayed MIC values of 62.5 and 31.25 microg/mL, respectively, against M. avium. All compounds were inactive against M. kansasii. These are promising results concerning the search for biologically active natural products, highlighting that new approaches to the prevention, treatment, and cure of tuberculosis are extremely important.
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| http://dx.doi.org/10.1515/znc-2009-11-1204 | DOI Listing |
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