Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806035 | PMC |
| http://dx.doi.org/10.18632/aging.100057 | DOI Listing |
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