The antimicrobial resistance of gram-negative pathogens has become problematic. In some cases related to Pseudomonas spp. and Acinetobacter spp., no antimicrobials on the market can be utilized at standard doses. We report a case of resistant Acinetobacter infection in a patient in the intensive care unit. In this scenario, we successfully treated the infection with doripenem at a higher dose of 1 g with a 4-hour infusion time along with the combination of tigecycline and colistin.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804493PMC
http://dx.doi.org/10.1080/08998280.2010.11928578DOI Listing

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