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Human parvovirus B19 typically causes erythema infectiosum, but unusual exanthems and hemorrhagic manifestations, such as purpuric-petechial rashes, have also been reported. PVB19-associated purpuric-petechial eruption (PAPPE) should be recognized as a distinct clinical feature of primary parvovirus B19 infection and considered in the differential diagnosis of patients with febrile purpura. This report aims to highlight several scenarios of B19V-associated petechial and purpuric rashes, which may present to pediatric departments during outbreaks.

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Article Synopsis
  • Urticarial vasculitis is a condition marked by long-lasting hives and can be triggered by medications, infections, autoimmune disorders, or, as noted, certain vaccinations.
  • The case study discusses a 67-year-old woman who developed a rash three days post-influenza vaccination, leading to a diagnosis of normocomplementemic urticarial vasculitis, which resolved after treatment.
  • The review highlights that while vaccine-associated vasculitis is common, urticarial vasculitis after vaccination is rare, and the underlying mechanisms are not well understood, suggesting a need for further research.
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