AI Article Synopsis
- The study examined the relationship between HIV-1 DNA levels and patient outcomes in HIV lymphoma patients undergoing high-dose chemotherapy followed by stem cell transplantation.
- HIV DNA levels correlated with HIV RNA levels but not with CD4(+) counts, and they remained detectable over time despite controlled HIV RNA.
- Higher baseline HIV DNA levels were associated with a significantly increased risk of death, suggesting that baseline HIV DNA can be a predictor of overall survival in these patients.
Article Abstract
The kinetics and predictive value of HIV-1 DNA (HIV DNA) levels in relapsed or refractory HIV lymphoma patients, treated with high-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT), were investigated. HIV DNA was measured by real-time PCR in the peripheral blood mononuclear cells (PBMCs) of 22 patients observed for a median follow-up of 31.0 months. At baseline, HIV DNA was found to be correlated with HIV-1 RNA (HIV RNA) (r = 0.56), but not with CD4(+) counts (r = -0.10). HIV RNA load was under control for the entire follow-up, while HIV DNA levels were almost always detectable (baseline levels vs. 1 year from ASCT levels, p > 0.05). Baseline HIV DNA levels were significantly different between alive and deceased patients (p = 0.03), and the overall survival (OS) analysis showed that for patients with higher HIV DNA levels at baseline there was a higher and nearly significant risk of death if compared to patients with lower levels (HR, 8.33, 95% CI, 0.99-70.06, p = 0.05). Our study demonstrated that high HIV DNA levels at baseline could predict overall survival after ASCT in one of the largest cohorts of HIV lymphoma patients treated with salvage therapy.
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| http://dx.doi.org/10.1089/aid.2009.0081 | DOI Listing |
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