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[Disease burden of communicable diseases among children and adolescents aged under 20 years in China from 1990 to 2021].
Zhongguo Dang Dai Er Ke Za Zhi
January 2025
Department of Pediatrics, Third Xiangya Hospital of Central South University, Changsha 410013, China.
Objectives: To investigate the epidemiological characteristics and changing trends of communicable diseases among children and adolescents in China from 1990 to 2021.
Methods: Based on the Global Burden of Disease Database, epidemiological indicators for communicable diseases among the population aged under 20 years in China from 1990 to 2021 were selected to analyze the burden of communicable diseases in this population, and a comparative analysis was performed with global data as well as data from Western Europe and North America.
Results: In 1990-2021, the overall burden of communicable diseases tended to decrease among children and adolescents in China.
Gaps and Barriers to the Implementation of Antimicrobial Stewardship Programmes in Hospitals of Pakistan.
J Coll Physicians Surg Pak
January 2025
Department of Pathology, Peshawar Institute of Cardiology-MTI, Peshawar, Pakistan.
Antimicrobial-resistant bacteria are particularly prevalent in Southeast Asia, mainly due to inadequate infection prevention and control (IPC) and the widespread and uncontrolled use of antibiotics. Pakistan is the third largest low-middle-income country (LMIC) user of antibiotics. Antibiotic consumption increased by 65%, from 800 million to 1.
View Article and Find Full Text PDFIntercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells.
Mol Cancer
January 2025
Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Background And Aims: Oncogenic KRAS mutations are present in approximately 90% of pancreatic ductal adenocarcinoma (PDAC). However, Kras mutation alone is insufficient to transform precancerous cells into metastatic PDAC. This study investigates how KRAS-mutated epithelial cells acquire the capacity to escape senescence or even immune clearance, thereby progressing to advanced PDAC.
View Article and Find Full Text PDFComparing different timings of tourniquet application in total knee arthroplasty: effects on postoperative pain and bone cement interface.
J Orthop Surg Res
January 2025
Department of Orthopaedics, FuyangHospital of Anhui Medical University, Fuyang, Anhui, China.
Objective: This study aims to elucidate the impact of varying tourniquet application timings on postoperative pain and the bone cement interface following TKA.
Method: Patients who underwent TKA in our department between March 2021 and July 2023 were included in this study. They were randomly assigned to three groups: Group 1 used tourniquets throughout the operation, Group 2 applied tourniquets before the osteotomy, and Group 3 applied tourniquets after completing the osteotomy.
Purpose: Both clinical knowledge and patient care ownership (PCO) are crucial to the provision of quality patient care and should be acquired during training. However, the association between these two concepts is under-examined. Here, we conducted a nationwide cross-sectional study to investigate the association between clinical knowledge and PCO among resident physicians in Japan.
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