The hypothesis that changes in measured ground reaction forces and time parameters during locomotion can noninvasively detect Parkinsonism in unilateral 6-OH dopamine (6-OHDA) lesioned rats is tested. It was found that changes of seven locomotion parameters can be used to construct a logistic regression model with a detection sensitivity and specificity of over 90% as compared to non-lesioned rats. Comparisons between this model and other neurological and neuromuscular disorders are presented.
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| http://dx.doi.org/10.1016/j.bbr.2010.02.012 | DOI Listing |
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