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Strongyloides hyperinfection and disseminated infections are usually associated with immunosuppression; these severe manifestations occur in a minority of cases. The use of immunosuppressants such as corticosteroids and Baricitinib for treating COVID-19 pneumonia can be responsible for patients' immunosuppression and cause Strongyloides hyperinfection syndrome. The chance increases when the patient belongs to countries or regions where chronic infection with Strongyloides is more prevalent.
View Article and Find Full Text PDFPopulation Pharmacokinetics and Exposure-Response Analysis of a Fixed-Dose Combination of Ivermectin and Albendazole in Children, Adolescents, and Adults.
Clin Pharmacol Ther
January 2025
Barcelona Institute for Global Health (ISGlobal), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
Article Synopsis
- Trichuris trichiura is a parasitic worm causing intestinal issues, and the typical treatment is albendazole, which works better when combined with ivermectin.
- This article focuses on developing pharmacokinetic models and understanding how this drug combination works based on data from clinical trials involving healthy adults and infected children and adolescents.
- Findings showed both drugs had similar absorption characteristics, and the chosen dosages in the trial were deemed suitable for future testing in larger studies.
Beyond the norm: Illuminating eosinophilic ascites with 2 rare and intriguing cases.
Radiol Case Rep
November 2024
Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco.
Article Synopsis
- - Eosinophilic ascites (EA) is a rare condition marked by high eosinophil levels in abdominal fluid, often linked to eosinophilic gastroenteritis and parasitic infections.
- - Two cases from a gastroenterology department illustrate EA: one patient improved with Albendazole after diagnosis, while another showed positive results from empirical treatment for eosinophilic leukocytosis.
- - Effective diagnosis of EA relies on lab analysis and histological methods, with corticosteroids used as a main treatment after addressing any underlying parasitic infections, highlighting the importance of educational efforts to prevent such infections.
Syndrome of inappropriate anti-diuretic hormone secretion secondary to disseminated strongyloidiasis in a kidney transplant recipient: A case report.
Heliyon
July 2024
Urinary Nephropathy Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Article Synopsis
- - A 43-year-old male kidney transplant recipient developed severe SIADH due to a disseminated Strongyloides stercoralis infection after consuming undercooked eel and sashimi.
- - The patient exhibited gastrointestinal symptoms and persistent low sodium levels, leading to the diagnosis of SIADH; testing confirmed the presence of the parasite.
- - Treatment with ivermectin proved effective, resolving both the SIADH and symptoms, highlighting the need for screening and awareness of this infection in transplant patients.
Trichinellosis-Induced Eosinophilic Myocarditis Mimicking Hypereosinophilic Syndrome.
Cureus
April 2024
Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.
is an uncommon parasitic disease contracted through the consumption of undercooked pork. We report the case of a 59-year-old man with a history of bicuspid aortic valve with recent travel to the Philippines and consumption of raw pork presenting with progressive myalgia and hypereosinophilia (nadir 12,940/uL) in profound cardiogenic shock in the setting of critical aortic stenosis. He underwent emergent balloon valvuloplasty, which was complicated by aortic insufficiency.
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