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Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii. | LitMetric
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Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii.

Yusuke Hirasawa Tomokazu Shoji Takashi Arai Alfarius E Nugroho Jun Deguchi Takahiro Hosoya Nahoko Uchiyama Yukihiro Goda Khalijah Awang A Hamid A Hadi Motoo Shiro Hiroshi Morita

Bioorg Med Chem Lett

Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

Published: March 2010

A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines.

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 Source
http://dx.doi.org/10.1016/j.bmcl.2010.01.051DOI Listing

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