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A catalytic perspective to nanomaterials reactivity-based toxicity; implications for single- and multiple-component nanomaterials (nanocomposites).
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CSIC - Insituto de Catálisis y Petroleoquímica, Madrid, Spain.
The extended use of a given product normally precedes concerns about it. The reactivity-based nanotoxicity is a major concern that must be tackled from its fundamental understanding to its regulatory management. Moreover, concepts and ideas must seamlessly flow between relevant performers.
View Article and Find Full Text PDFMechanistic insights into ruxolitinib cream for mild hidradenitis suppurativa.
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Janus-like behavior of intrinsically disordered regions in reticulophagy.
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School of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.
Intrinsically disordered regions (IDRs) are crucial to homeostatic and organellar remodeling pathways. In reticulophagy/ER-phagy, long cytosolic IDR-containing receptors (e.g.
View Article and Find Full Text PDFPotential of ginsenoside Rg1 to treat aplastic anemia mitogen activated protein kinase pathway in cyclophosphamide-induced myelosuppression mouse model.
World J Stem Cells
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Biological and Chemical Engineering, Hongik University, Sejong 30016, South Korea.
Aplastic anemia (AA) is a rare but serious condition in which the bone marrow fails to produce sufficient new blood cells, leading to fatigue, increased susceptibility to infection, and uncontrolled bleeding. In this editorial, we review and comment on an article by Wang published in 2024. This study aimed to evaluate the potential therapeutic benefits of ginsenoside Rg1 in AA, focusing on its protective effects and uncovering the underlying mechanisms.
View Article and Find Full Text PDFIs 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma?
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November 2024
Hepatosplenic Surgery Center, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Article Synopsis
- The article discusses the challenges of treating intrahepatic cholangiocarcinoma (iCCA), as most patients do not respond well to existing therapies and highlights ongoing efforts to find new molecular targets.
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